Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Data summary: IL 4 regulates glutathione levels in the liver and lung Download Scientific Diagram Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it