Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis Glucose 6 phosphate dehydrogenase deficiency The Lancet Glucose 6 Phosphate Dehydrogenase deficiency G6PD deficiency, features, Offending & Safe drugs Loss of glucose 6 phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells PNAS G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( G6PD Deficiency. Treatment with Our Supplements.