Mara Ever wondered what those little brown spots are that are often found on the lip? Many refer to them as a freckle but the medical term is melanotic macules. Lip Pigmentation Removal with Laser Ensoul Medical Clinic Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Labial melanotic macule Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in