Don't Suppress a Fever Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol (acetaminophen) may seem harmless But it could be working against your body's ability to heal. Depletes glutathione, your body's master antioxidant (Prescott, J Clin Invest, 1982) Glutathione is Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Oral magnesium prevents acetaminophen induced acute liver injury by modulating microbial metabolism ScienceDirect Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA