Efficacy of Oral N Acetylcysteine in the Treatment of Acetaminophen Overdose New England Journal of Medicine For generations, families have trusted Tylenol when it matters most. Why? Because Tylenol is one of the most studied medications in history. L Glutathione Best Glutathione Supplement: What's Your Best Option? GoodRx Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of ExtendedRelease and ImmediateRelease Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym Beaudoin