As per my latest article, if you use PPIs chronically, and you're experiencing worsening of migraine symptoms, ask your neurologist if you should try supplementing with magnesium and check your B12. : Real Gluteal I.M Injection Demonstration I Feel Tired All the Time. Do I Need a B12 Shot?: Shawn Veiseh, M.D.: Family Medicine Are vitamins supplements triggers for migraines? I once decided to take multivitamins as a cure as I felt tired. Result, few hours after the first pill, it was headache then migraine. Then Self injection guide: How to give yourself a subcutaneous injection B12 Shots at Home: How, Where & How Often to Inject Yourself AZ IV Medics