In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease Mini MCAT passage: Pentose phosphate pathway and G6DP deficiency (practice) Khan Academy Glucose 6 phosphate dehydrogenase (G6PD) deficiency: Video, Causes, & Meaning Osmosis Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Glucose 6 Phosphate Dehydrogenase Deficiency