Glutathione & Diabetes: How the Body's Master Antioxidant Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione synthetase deficiency MedLink Neurology Glutathione deficiency and heart failure: a systematic review of human and animal evidence ScienceDirect Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis