Oral Melanotic Macule: Symptoms and Treatment Skinsight This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar AD :: Annals of Dermatology Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology