Ergothioneine: An Antioxidative, Neuroprotective and Anti Inflammatory Compound from Mushroom Residuals Mushrooms (especially porcini) contain the highest levels of 2 powerful antioxidants, ergothioneine and glutathione, the latter of which is sometimes called the mother of all antioxidants and is a very important bodily Ergothioneine: an antioxidant with high potential In a study, researchers found that mushrooms have high amounts of the ergothioneine and glutathione, both important antioxidants, said the senior author. The researchers also found that the amounts the two compounds Ergothioneine rich mushrooms may fight depression, finds US study Frontiers Mushroom marvels: understanding their role in human health