Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Oral Melanotic Macule: Symptoms and Treatment Skinsight QSwitched 785 nm laser in the treatment of labial melanotic macules Gallo 2024 Skin Research and Technology Wiley Online Library