Paraxanthine may represent the next wave of clean energy drinks with smoother stimulation, fewer jitters, and potentially better focus. A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis ScienceDirect Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation 93% of Americans use caffeine daily, but nearly 50% are slow caffeine metabolizers?! That means millions of people experience more crashes, anxiety, and sleep issues from their morning coffee than the clean Tea and BloodBrain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies Yue 2025 Food Frontiers Wiley Online Library Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue Nature Protocols