What Caused These Multiple Hyperpigmented Macules of the Mouth? Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Labial melanotic macule Genital melanotic macules: Clinical, histologic, immunohistochemical, and ultrastructural features Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Clinician's Update on the Benign, Premalignant, and Malignant Skin Tumours of the Vulva: The Dermatologist's View Sand 2017 International Scholarly Research Notices Wiley Online Library