Paracetamol (Acetaminophen) hepatotoxicity and its management. Biotransformations Leading to Toxic Metabolites: Chemical Aspects ScienceDirect Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting, Immune mechanisms in acetaminophen induced acute liver failure Krenkel HepatoBiliary Surgery and Nutrition Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N acetyl p benzoquinone imine with deoxyguanosine and glutathione ScienceDirect