Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Tylenol and Glutathione: A Closer Look At Their Relationship Glutathione detoxes tylenol and environmental toxins A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol And Glutathione Invigor Medical Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development.