Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect How Acetaminophen Causes Liver Failure Biocompare: The Buyer's Guide for Life Scientists Tylenol & Glutathione: Lets Clear the Air! , Theres been a lot of buzz lately about Tylenol (acetaminophen) and its effect on glutathione levels. So, lets break it down and address those Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: