When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy Tylenol lowers glutathione, which is why it can cause liver failure. Low glutathione can cause many serious health problems that can vary from person to person. Finding out if you have genes that can Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and What to Avoid When Taking Glutathione Thornhill's Pharmacy Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Is it safe to drink while taking Tylenol?