Mast Cell Activation Syndrome (MCAS) Dr. Todd Maderis Master Antioxidant Therapy Glutathione IV Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Glutathione (GSH), a powerful intracellular antioxidant, plays a Download Scientific Diagram Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.