The conjugation of acetaminophen by glutathione and cytochrome P450. Download Scientific Diagram Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Dr. Laura E. Riley joined @GoodMorningAmerica recently to clear up some lingering confusion about Tylenol (acetaminophen) use during pregnancy. A new study from the University of London found that acetaminophen is safe