Labial melanotic macule Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Not Cancer! Understanding Dark Spots in the Mouth, Have you noticed a dark spot on your lips, gums, or inside your mouth? Dont panic! In this video, Dr. Shifali Arora explains melanotic macules a Man Concerned About a New Spot On His Lip Let's Diagnose VisualDx COM Jan. 2008 Diagnosis UW School of Dentistry