Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury Katelyn A. Martino, Arush Nakhre, Renee M. Demarest, David M. Devilbiss, 2025 Frontiers HGF and MET: From Brain Development to Neurological Disorders Frontiers HGF and MET: From Brain Development to Neurological Disorders Artificial human Met agonists based on macrocycle scaffolds Nature Communications Unveiling the Role of HGF c Met Signaling in Non Small Cell Lung Cancer Tumor Microenvironment
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