Can paracetamol (acetaminophen) be administered to patients with liver impairment? Hayward 2016 British Journal of Clinical Pharmacology Wiley Online Library Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Tylenol's Impact on Glutathione and Liver Damage Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which