Transcription Factor Nrf2 Is Essential for Induction of NAD(P)H:Quinone Oxidoreductase 1, Glutathione S Transferases, and Glutamate Cysteine Ligase by Broccoli Seeds and Isothiocyanates The Journal of Nutrition Frontiers Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action What to Avoid When Taking Glutathione Thornhill's Pharmacy Cellular Guard by BODYHEALTH Sulforaphane & Antioxidant Support BodyHealth.com LLC Acetaminophen metabolism. Acetaminophen is metabolized primarily by Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.