A guide to managing acute liver failure Cleveland Clinic Journal of Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Tylenol And Glutathione Invigor Medical Tylenol (acetaminophen) is one of the most commonly used painkillers. It is safe for kids, during pregnancy, and while breastfeeding. However, just because it is safe, doesn't mean that it What to Avoid When Taking Glutathione 7 Crucial Facts