The Multiple Roles of Glucose 6 Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance G6pd glucose6phosphate dehydrogenase pathway vector illustration graphic Premium Vector G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Metabolism in erythrocytes Role of G6PD in preventing RBC destruction Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz