Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Benefits of Glutathione Helps Detox Your Liver And Muc Water for Health Glutathione Depleting Pro Oxidant as a Selective Anticancer Therapeutic Agent ACS Omega What Happens When You Stop Taking Glutathione? Route2Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.