Vitamin B12 Benefits and Best Sources Vitamin B12 study hints at a molecular mechanism for acne pathogenesis The Pharmaceutical Journal Is your B12 supplement causing your breakouts? It sounds like a paradox: you take vitamins to be healthy, but your skin starts acting up. While Vitamin B12 is essential for your Can B12 and Biotin Cause Acne? Emilia Nutrition Did you know that B12 supplements can significantly contribute to acne? , Ive seen it time and time again with my clientsmany experience stubborn breakouts that clear up once they stop Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals.