Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Sex differences in glutathione metabolism and acetaminophen toxicity Taking Tylenol? The Glutathione Connection Dr. Green Mom Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Regeneration and Recovery after Acetaminophen Hepatotoxicity Jenny McCarthy's Glutathione and Tylenol Claims: Medical Toxicologist Weighs In MedPage Today