Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Just say NO to Tylenol Ln Nch Glutathione: Xu Hng Mi Dng Da Vng Di Cnh Tay Myhaelyn Vietnam Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Tylenol's Impact on Glutathione and Liver Damage Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports