Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Taking Tylenol? The Glutathione Connection Dr. Green Mom Sex differences in glutathione metabolism and acetaminophen toxicity Eat These Foods to Increase Glutathione in Your Body Vitality Medical Wellness Center Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine