g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Sex differences in glutathione metabolism and acetaminophen toxicity Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.