Role of Glucose 6 Phosphate Dehydrogenase (G6PD) in the Pathophysiol ogy of Cataract. Glucose 6 phosphate dehydrogenase (G6PD): Response of the human erythrocyte and another cells to the decrease in their activity The Guardian of the RBC: Mastering G6PD Deficiency! #USMLEStep1 #MedEd #Biochemistry #Hematology #G6PD #HemolyticAnemia #Step1Prep #HighYield #MedSchool #BiteCells #HeinzBodies #Genetics #FutureDoctor #StudyGram #MedTwitter https Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Clinical Pharmacology & Toxicology Pearl of the Week