Labial melanotic macule Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with Skin Cancer Warning Signs Associated Dermatology & Skin Cancer Clinic Dark spot on lip had for 2 3 years but got bigger and darker over time no idea what it is but I don't like it anyone know? : r Dermatology This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor