OXIDATIVE STRESScan contribute to hypothyroid symptoms When the body has to deal with too much Oxidative Stress from inflammation, then the enzyme Glutathione Peroxidase [GPx] has to work overtime to inactivate damaging " Glutathione for Thyroid Health Victoriahealth.com Ltd Glutathione deficiency and heart failure: a systematic review of human and animal evidence ScienceDirect Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer Scientific Reports Hypothyroidism (underactive thyroid) is more common in people with Down syndrome. About 40% of the adolescents and adults with Down syndrome we have seen at our clinic have hypothyroidism. One of the Raised plasma glutathione S transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement The BMJ