Combination studies of platinum( ii ) based metallointercalators with buthionine S , R sulfoximine, 3 bromopyruvate, cisplatin or carboplatin Metallomics (RSC Publishing) DOI:10.1039 C3MT00191A Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: Roles of the NF B and MAPK signaling pathways Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis Cell Death & Disease Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma ScienceDirect Full article: Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta analysis of preclinical studies The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis American Journal of Physiology Gastrointestinal and Liver Physiology American Physiological Society