Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Tylenol depletes something called glutathione. Glutathione is a master antioxidant and your first line of protection against environmental toxins. It detoxifies and protects your cells. It protects your immune system and g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Acetaminophen Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review