The Truth About Paracetamol and Glutathione Levels Did you know that drugs like Tylenol and ibuprofen deplete the body's chief detoxifier, GLUTATHIONE? This is a BIG DEAL. Glutathione is essential not only for detox but also IMMUNE function, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology A Practical Approach to Avoiding Drug Nutrient Depletions NBI Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect