The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports