An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Oral Melanotic Macule: Symptoms and Treatment Skinsight Semaglutide Maintenance Dose Every Other Week: Safety and FDA Guidelines Fella Health Understanding Lip Spot Causes and Treatments Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Are Freckles on Lips a Cause for Concern? Causes, Remedies