Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Lip pigmentation Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor A collection of resources for RACGP exams Next Gen GP Text Book live webinars AKT and KFP questions Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in