GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Biochemistry Metabolism of acetaminophen (paracetamol) . Acetaminophen is widely used as a painkiller. Taken in the usual therapeutic doses, it is Instagram Sex differences in glutathione metabolism and acetaminophen toxicity Tylenol's Impact on Glutathione and Liver Damage Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect