The History of Acetaminophen Office for Science and Society McGill University Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Glutathione, Tylenol & Your Health: What You Should Know Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours.