Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Sex differences in glutathione metabolism and acetaminophen toxicity Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors NSAIDs & Acetaminophen: ditki medical and biological sciences