Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases Glutathione Metabolism and Its Implications for Health ScienceDirect Glutathione (GSH), the body's primary intracellular antioxidant, plays a fundamental role in maintaining redox balance and detoxification. In normal physiology, this is protective. However, in oncology, the picture becomes more nuanced. Emerging Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Full article: The central role of glutathione in the pathophysiology of human diseases