The Case Severe high anion gap metabolic acidosis Kidney International Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Paracetamol toxicity Biochemical Basis Lecture Are some people at increased risk of paracetamol induced liver injury? A critical review of the literature European Journal of Clinical Pharmacology Springer Nature Link
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paracetamol and glutathione depletion Paracetamol is one of the most commonly used analgesic and antipyretic drugs