Small Molecule AngIV based Analogs to Treat Alzheimers Disease Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa c Met HGFR TargetMol C Met wikidoc Small molecule activation of the neurotrophin hepatocyte growth factor to treat Alzheimer disease HGF c Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR NGF axis Cell Death & Disease