What Caused These Multiple Hyperpigmented Macules of the Mouth? Labial melanotic macule Labial melanotic macule Stock Image C057 2077 Science Photo Library Melanotic Macules, Naevi, and Melanoma Springer Nature Link Clinical Challenge: Dark Lesion on Lower Lip MPR Spot the Dot! Growths on the lips are not too common. Clinically, this was consistent with a labial melanotic macule (aka freckle on the lip). These are benign growths which can be