Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Solved The following figure shows the metabolism of the Chegg.com Acetaminophen Pathway (toxic doses), Pharmacokinetics