Psychopharmacology Debates: Tylenol or NSAIDs? Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy