Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Tylenol Glutathione Kizer Wellness LLC The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Don't Suppress a Fever 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network